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Please register for 

Molecular Modeling as a Screening Tool to Predict the Separation of Enantiomers On Polysaccharide-based Chiral Stationary Phases 

When: Oct 10, 2018 12:00 PM EDT
Registration link: https://attendee.gotowebinar.com/register/6581171220259490305

Speakers:

Dr. Priyanka Sharma, co-CEO, Kazmira LLC
Dr. David House, Research Fellow and Director of Chemistry, Orochem
Dr. Sohail Murad, Professor and Chair of Dept. of Chemical and Biological Engineering, Illinois Institute of Technology
Pulak Sharma, co-CEO, Kazmira LLC

In this seminar, we explore the power of computational molecular modeling to develop an efficient (time and cost) and reliable software package for screening the separation of enantiomers on polysaccharide-based chiral stationary phases. More than half of all pharmaceuticals are chiral compounds and the potential market for enantiomer separation is $1.2 billion. Although enantiomers of chiral compounds have the same chemical structure, they can exhibit marked differences in physiological activity; therefore, it is important to remove the undesirable enantiomer. 

Chromatographic separation of chiral enantiomers is one of the best available methods to obtain enantio-pure substances, but the optimization of the experimental conditions can be very time-consuming and expensive. The large number of chiral compounds, mobile phase possibilities, and chiral phases can lead to hundreds of possible combinations. Typically, the industry relies on educated guessing and chromatographers try many different combinations. This has hindered progress for developing new drugs, especially orphan drugs. Our software package will allow the initial screening to be done computationally with only a limited number of experimental studies needed to complete a project. 

Key Learning Objectives: 
• Understand the power of molecular modeling for screening studies of chiral separations
• Optimize operating conditions using the developed tools
• Strategies for developing new column morphologies for separations

About Orochem:
Orochem has manufactured sample preparation, chromatography and protein research products in USA over 22 years. It invests heavily in R&D in-house and owns strong intellectual property in stationary phases for achiral and Chiral Chromatography

After registering, you will receive a confirmation email containing information about joining the webinar.

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                  EVENT INTRO

                     2018 Chinese American

              Chromatography Association (CACA)

                               Virtual symposium


       HYDROPHILIC INTERACTION

           CHROMATOGRAPHY (HILIC)

                             DATE: WEDNESDAY, SEPTEMBER 26th, 2018

                                                  TIME: 12-3 pm EST

                                                 REGISTRATION URL:

         https://attendee.gotowebinar.com/register/3117775562001844227

 

                                                 REPLAY URL:

         https://attendee.gotowebinar.com/recording/1675879315313332227

 

                      Celebrating the 10-year anniversary of

          the Chinese American Chromatography Association

                                (CACA, www.ca-ca.org)


      for more information contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

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Please register for

Changing the Playing Field of Micro-LC: Balancing Sensitivity Without Jeopardizing Ruggedness and Reliability

Mar 28, 2018 12:00 PM EDT at: 

https://attendee.gotowebinar.com/register/4752375517463258626

Kenneth HellsternKenneth Hellstern 
Senior Field Sales Engineer, Western & Central New York 
Shimadzu Scientific Instruments, Inc. 


In this seminar, we explore the ever changing filed of liquid chromatography. We investigate the middle ground between Nano-LC and UHPLC/HPLC; Micro-LC. We discuss what is Micro-LC and how it changes the playing field, what advantages does it bring to the chromatographer but also why it is not widely used at this time. Based on our findings, we will investigate the creation of a product that is developed around the unique physics of the µLC/LCMS technique. We will discover how the product can resolve the problems of the past without jeopardizing productivity and robustness. 


Key Learning Objectives: 

  • Understanding the caveats of Nano-LC and Micro-LC 
  • How utilizing micro-LC may maximize sensitivity 
  • Simplifying the micro-LC connection with UF-Link 
  • How to achieve high sensitivity with a low dead-volume μLCMS Interface. 

 

Who Should Attend:

  • Method developers for micro LC methods in pharmaceutical, chemical, clinical, environmental, agrichemical, contract research organization, university and governmental laboratories.
  • Method developers analyzing large and/or small molecules at trace amount. 

 

About Shimadzu 

Shimadzu Scientific Instruments (SSI) is the American subsidiary of Shimadzu Corporation. Founded in 1875, Shimadzu is a $3 billion multinational corporation with three major divisions: Medical Diagnostics, Aerospace/Industrial, and Analytical Instruments. The Analytical Division is one of the world's largest manufacturers of analytical instrumentation and environmental monitoring equipment. In addition to Japan, Shimadzu products are manufactured in China, the Philippines, the U.K., and in Oregon US.

After registering, you will receive a confirmation email containing information about joining the webinar.