Accelerating UHPLC / HPLC Method Development Strategies by Leveraging Selectivity: Influence of Unique-C18 based Stationary Phases

Alan P McKeown BSc, PhD, CChem, FRSC
Global Business Development Director
Advanced Chromatography Technologies

Wednesday, November 23rd, 2016 12:00 – 1:00 pm EST

Event Overview:

In this seminar, we explore the power of stationary phase design to impact selectivity to maximize resolution. Using a variety of chromatographic data, we discuss how incorporating different modes of interaction during method development including hydrophobic, π-π, dipole-dipole and shape selectivity influences selectivity of reversed phase separations.

The potent combination of these mechanisms in each unique-C18 based phase provides a new option for the chromatographer involved in method development or high-throughput screening to move peaks around in the separation space easily and without compromising separation knowledge. This is further underlined by phase characterization data and also selectivity plots which indicate a high degree of orthogonality when designing stationary phases that impact multiple modes of interaction.

Key Learning Objectives:

• Utilize chromatographic selectivity to maximize resolution
• Neue Selectivity Descriptor – how to calculate S for your separations
• Optimize HPLC / UHPLC method development workflows

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