Education: The Scripps Research Institute: research associate 1992-1996.
UCLA: Postdoctoral 1991-1992.
Harvard University: Ph.D., 1991.
Lanzhou University: B.Sc. in Chemistry, 1984.
UCLA: Postdoctoral 1991-1992.
Harvard University: Ph.D., 1991.
Lanzhou University: B.Sc. in Chemistry, 1984.
Professional Positions:
Assistant Professor of Chemistry, Vanderbilt University, 9/1996-7/2003.
Associate Professor of Chemistry, Mississippi State University, 8/2003-12/2007.
Adjunct Professor of Chemistry, Mississippi State University, 1/2008-Present.
Program Director, Division of Chemistry, National Science Foundation, 1/2006-present.
Honors and awards:
Research featured in Analytical Chemistry, A-page, “Selecting the selectors”, August 1, 1999, 517A.
Paper selected by the editor as an accelerated article. “Screening of random combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries”, Anal. Chem. 1999, 71, 1688-1691.
Paper (Nature, 1996, 379, 326-327) was chosen as a remarkable paper of 1996 by Japan's Chemistry journal.
Paper (Science, 1994, 264, 1289-1293) was featured in Chemical & Engineering News, “Antibody Catalyzed Cationic Cyclization”, June 13, 1994, pp 43-44.
Publications:
Chromatography related:
Louis H. Bluhm, Tingyu Li, “Chromatographic purification of quaternary ammonium and pyridinium ions on normal phase silica gel”, Tetrahedron Letters, 1998, 39, 3623-3626.
Yongqing Wu, Michelle Krocka, Tingyu Li, “Noncovalent linking of a chiral selector to unmodified silica gel through amine functional groups”, J. Chromatogr., A., 1998, 822, 11-18.
Anle Yang, Tingyu Li, “Oxidative cleavage of carbon-silicon bond as a new method to characterize bonded stationary phases on silica gel”, Anal. Chem., 1998, 70, 2827-2830.
Yongqing Wu, Yan Wang, Anle Yang, Tingyu Li, “Screening of mixture combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries”, Anal. Chem. 1999, 71, 1688-1691. Published as an accelerated article.
Louis H. Bluhm, Tingyu Li , “The effect of analog ions in normal phase ion-pair chromatography of quaternary ammonium compounds”, J. Chromatogr. Sci., 1999, 37, 273-276.
Yan Wang, Tingyu Li, “Screening of a parallel combinatorial library for selectors for chiral chromatography”, Anal. Chem.,1999, 71, 4178-4182.
Anle Yang, Andrew Gehring, Tingyu Li, “Large degree of racemization observed in the amide bond forming reactions on silica gel”, J. Chromatogr., A.. 2000, 878, 165-170.
Louis H. Bluhm, Yan Wang, Tingyu Li, “An Alternative Procedure to Screen Mixture Combinatorial Libraries for Selectors for Chiral Chromatography”, Anal. Chem., 2000, 72, 5201-5205.
Yan Wang, Louis H. Bluhm, Tingyu Li, “Identification of Chiral Selectors from a 200-Member Parallel Combinatorial Library”, Anal. Chem., 2000, 72, 5459-5465.
Yan Wang, Tingyu Li, “Identification of affinity ligands for protein purification from synthetic chemical combinatorial libraries ”, Biotechnology Progress, 2002, 18(3), 524-529.
Andew P. Gehring, Louis H. Bluhm, Yufeng Ma, Tingyu Li, “Solvents effects on the screening of parallel combinatorial libraries for selectors for chiral chromatography”, 2002, 40(7), 383-386.
L. H. Bluhm, T. Li, “The role of analogue ions in the ion-pair reversed phase chromatography of quateranry ammonium compounds’, J. Chromato. Sci. 2003, 41(1), 6-9
Jordan Blodgett, Yan Wang, Louis H. Bluhm, Tingyu Li*, Prasad L. Polavarapu, J. Drabowic, K. M. Pietrusiewicz, and K. Zygo“Resolution of a phosphorus containing compound using selectors identified from a chemical combinatorial library”, Anal. Chem. 2002, 74, 5212-5216.
Feng Wang, Yan Wang, Prasad L. Polavarapu*, Tingyu Li, J. Drabowicz, K. M. Pietrusiewicz, K. Zygo, “Absolute configuration of tert-butyl-1-(2-methylnaphthyl)phosphine oxide”, J. Org. Chem. 2002, 67, 6539-6541.
Tingyu Li, Yan Wang, Louis H. Bluhm, “Resolving Racemic Mixtures Using Parallel Combinatorial Libraries”in “Combinatorial Library: Methods and Protocols”, Lisa Bellavance English, Ed.; Humana Press; pp 203-215; 2002
Yan Wang, Tingyu Li "Multiple peak formation of undenatured protein on an affinity support: a possible source of low protein mass recovery", J. Chromatogr. Sci. 2004, 42, 85-87.
Tingyu Li, "Weight adjustment in calculating surface ligand coverage or density for chromatographic bonded phases", J. Chromatogr., A., 2004, 1035, 151-152.
Jordan Blodgett, Tingyu Li "The 4-t-butylphenyl group as a simple tag for solution phase synthesis", Tetrahedron Letters, 2004, 45(35), 6649-6652.
Junmin Huang, Tingyu Li "Efficient resolution of racemic 1,1'-bi-2-naphthol with chiral selectors identified from a small library", J. Chromatogr., A. 2005, 1062, 87-93.
Junmin Huang, Peng Zhang, Hui Chen, Tingyu Li "Preparation and evaluation of proline based chiral columns", Anal. Chem.2005, 77(10), 3301-3308.
Amanda L. Norick, Tingyu Li "Study of the racemization observed in the amide bond forming reaction on silica gel", J. Chromatogr. Sci. 2005, 43 (10), 526-529.
Junmin Huang, Tingyu Li "Highly efficient chromatographic resolution of a,a'-dihydroxybiaryls", Organic Letters, 2005, 7, 5821-5823.
Louis H. BlLouis H.Bluhm, Junmin Huang, Tingyu Li "Recent Advances of Using Peptides as Chiral Selectors" to the special issue dedicated to separation science entitled "Advances in Separation Science" in Analytical and Bioanalytical Chemistry,2005, 382(3), 592-598.
Tingyu Li “Development of efficient chiral stationary phases from peptide libraries”, Lab plus international, 2005, 19(1), 15-18. On cover page.
Tingyu Li “Peptide and peptidomimetic chiral selectors in liquid chromatography”, J. Sep. Sci., 2005, 28, 1927-1931.
Junmin Huang, Hui Chen, Tingyu Li "Studies of the resolution of racemic 1,1'-bi-2-naphthol with a depeptide chiral selector identified from a small library ", J. Chromatogr., A. 2006, 1102, 176-183.
Junmin Huang, Hui Chen, Peng Zhang, Tingyu Li " Improvement of proline enantioselective stationary phases by replacing the 9-fluorenylmethoxycarbonyl group ", J. Chromatogr., A. 2006, 1109, 307-311.
Junmin Huang, Hui Chen, Tingyu Li " Improvement of proline chiral stationary phases by varying peptide length and linker ", J. Chromatogr., A. 2006, 1113, 109-115.
Peng Zhang, Prasad L. Polavarapu, Junmin Huang, and Tingyu Li “Spectroscopic rationalization of the separation abilities of decaproline chiral selector in dichloromethane-isopropanol solvent mixture”, Chirality, 2007, 19, 99-105.
Min Li, Tao Wang, Patrisha J. Pham, Charles U. Pittman, Jr., Tingyu Li, “Liquid phase extraction and separation of noble organometallic catalysts by functionalized ionic liquids”, Separation Science and Technology, 2008, 43, 1-14
Other Selected Publications:
1) Tingyu Li, Richard A. Lerner, and Kim D. Janda. “Antibody-catalyzed cationic reactions: rerouting of chemical transformations via antibody catalysis”. Acc. Chem. Res 1997, 30, 115-12.
2) Tingyu Li, Kim D. Janda, and Richard A. Lerner. “Cationic cyclopropanation: controlling the reaction routes of carbocations by antibody catalysis”. Nature. 1996, 379, 326-7.
3) Tingyu Li, Kim D. Janda “Synthesis of a bifunctional hapten designed to mimic both transition state and to induce bait and switch catalysis”. Bioorg. & Med. Chem. Letter 1995, 5, 2001-2004.
4) Jonathan Rosenblum, Lee-Chiang Lo, Tingyu Li, Kim D. Janda, and Richard A. Lerner. “Antibody-catalyzed hydrolysis of phosphate triesters: a class of compounds similar to those used in the recent Japanese subway poisoning”. Angew. Chem Int. Ed. Engl., 1995, 34, 2275-2277.
5) Tingyu Li, Susan Hilton, Kim D. Janda. “Remarkable ability of different antibody catalysis to control and diversify the product outcome of cationic cyclization reactions”. J. Am. Chem. Soc. 1995, 117, 3308-3309.
6) Tingyu Li, Kim D. Janda, Susan Hilton, and Richard A. Lerner. “An antibody catalyzed nucleophilic substitution at a primary carbon that appears to proceed by an ionization mechanism”. J. Am. Chem. Soc. 1995, 117, 2367-2368.
7) Tingyu Li, Susan Hilton, Kim D. Janda. “The Potential Application of Catalytic Antibodies to Protecting Group Removal: Catalytic Antibodies with Broad Substrate Tolerance”. J. Am. Chem. Soc. 1995, 117, 2123-2127.
8) Tingyu Li, Kim D. Janda, Jon A. Ashley, and Richard A. Lerner. “Antibody Catalyzed Cationic Cyclization”. Science, 1994, 264, 1289-1293. See also C&EN, June 13, 1994, p43-44.
9) Kim D. Janda, Chih-Hung L. Lo, Tingyu Li, Carlos F. Barbas III, Peter Wirsching, and Richard A. Lerner. “Direct Selection for a Catalytic Mechanism from Combinatorial Libraries”. Proc. Natl. Acad. Sci., USA, 1994, 91, 2532-2536.