Nowadays, many ways of performing a quantitative microsampling study are possible and every setting may have a most suitable microsampling technique. In this presentation we’ll discuss a selection of microsampling techniques, some latest yet unpublished research and an interesting new microsampling device.


Remco Koster, Ph.D                                                                                                                                              .Remco Koster
Sr. Scientist, Project Manager
PRA Health Sciences

Time:  Wed, Nov 14, 2018 12:00 PM - 1:00 PM EST

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Choosing the most suitable microsampling technique may depend on different factors like:

  •  Is blood or plasma desired as matrix for analysis?
  • Can accurate sampling be performed on location?
  • Are the costs for the required material and shipment of the samples an important factor?
  • Could the analytes irreversibly adsorb to the sampling material?

Capillary sampling can be used for plasma or whole blood analysis, while Dried Blood Spots (DBS) and Mitra VAMS can only be used for whole blood analysis and subsequent evaluation of the analysis data. While DBS may not be used in a FDA regulated setting (clinical studies) anymore, a setting which uses home sampling by patients themselves and uncooled transport of each single sample by mail to the laboratory may make DBS well suitable for this setting. The Mitra VAMS sampling tips may be an eligible successor for the DBS in this setting but may also be used in in a FDA regulated setting. Some analytes may adsorb to the sampling material like the cellulose of the Dried Blood Spot (DBS) card or material of the Mitra VAMS tip. The research into the analysis of immunosuppressants with the use of DBS showed adsorption effects, which varied per analyte, concentration and hematocrit value. Mitra sampling might be less hindered by this adsorption effect. The latest research investigated the analysis and adsorption of immunosuppressants in Mitra VAMS tips as alternative to DBS.

Key Learning Objectives:

  • Understand which microsampling technique is most suitable in which setting
  • Strategies for feasibility testing concerning the analyte extraction procedure and adsorption effects